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Research topics

Research at the PROVIDI Lab consists mainly of developing processing and visualization methodology for diffusion MRI to improve the reliability of quantitative analyses and to gain more insight into the fundamental properties of tissue microstructure. An overview of the research activities in Dutch can be found here.

The PROVIDI Lab also participates in several neuroscientific, clinical and biomedical research projects with topics such as normal brain development and aging, diabetes mellitus, vascular Parkinsonism, autism, and traumatic brain injury, among others. In addition to literature that reviews diffusion MRI concepts, a few representative research articles are provided below.

Background diffusion MRI

S. Deprez, T. Billiet, S. Sunaert, and A. Leemans, Diffusion tensor MRI of chemotherapy-induced cognitive impairment in non-CNS cancer patients: A review, Brain Imaging and Behavior, Vol. 7(4), p. 409-435, 2013 | PDF
J.D. Tournier, S. Mori, and A. Leemans, Diffusion tensor imaging and beyond, Magnetic Resonance in Medicine, Vol. 65(6), p. 1532-1556, 2011 | PDF
D.K. Jones and A. Leemans, Diffusion tensor imaging, Methods in Molecular Biology, Vol. 711, p. 127-144, 2011 | PDF

Diffusion MRI methodology

C.M.W. Tax, B. Jeurissen, S.B. Vos, M.A. Viergever, and A. Leemans, Recursive calibration of the fiber response function for spherical deconvolution of diffusion MRI data, NeuroImage Vol 86, p 67-80, 2014 | PDF
S.B. Vos, D.K. Jones, M.A. Viergever, and A. Leemans, Partial volume effect as a hidden covariate in DTI analyses, NeuroImage, Vol. 55(4), p. 1566-1576, 2011 | PDF
A. Leemans and D.K. Jones, The B-matrix must be rotated when correcting for subject motion in DTI data, Magnetic Resonance in Medicine, Vol. 62(1), p. 1336-1349, 2009 | PDF

Diffusion MRI applications

J. McGrath, K. Johnson, E. O'Hanlon, H. Garavan, L. Gallagher, and A. Leemans, White matter and visuospatial processing in autism: A constrained spherical deconvolution tractography study, Autism Research, Vol. 6(5), p. 307-319, 2013 | PDF
J.L. Hsu, Y.L. Chen, J.G. Leu, F.S. Jaw, C.H. Lee, Y.F. Tsai, C.Y. Hsu, C.H. Bai, and A. Leemans, Microstructural white matter abnormalities in type 2 diabetes mellitus: A diffusion tensor imaging study, NeuroImage, Vol. 59(2), p. 1098-1105, 2012 | PDF
P.K.N. van der Jagt, P. Dik, M. Froeling, T.C. Kwee, R.A.J. Nievelstein, B. ten Haken, and A. Leemans, Architectural configuration and microstructural properties of the sacral plexus: A diffusion tensor MRI and tractography study, NeuroImage, Vol. 62(3), p. 1792-1799, 2012 | PDF

© Copyright

The documents listed above are available for downloading. These have been provided as a means to ensure timely dissemination of scholarly and technical work on a non-commercial basis. Copyright and all rights therein are maintained by the authors or by other copyright holders, notwithstanding that they have offered their works here electronically. It is understood that all persons copying this information will adhere to the terms and constraints invoked by each author's copyright. These works may not be re-posted without the explicit permission of the copyright holder.

© 2022 – Alexander Leemans